Senior Scientist - Lead Optimisation Unit

Chugai Pharmabody Research Pte. Ltd. (“CPR”) was established in Singapore as a wholly-owned subsidiary of Chugai Pharmaceutical Co., Ltd (Chugai), a member of Roche group, in January 2012 and started operations on July 2, 2012. Located at Geneo in Singapore , it aims to generate new antibody drugs based on Chugai’s proprietary antibody engineering technologies, such as recycling antibody®, sweeping antibody®, bispecific antibody, various Fc engineered antibodies, and other new antibody engineering technologies that are under development. Position – Senior Scientist in Lead Optimisation Unit Overview CPR is seeking a motivated Senior Scientist with demonstrated expertise in protein engineering and a strong passion for medical science. This position offers the opportunity to contribute to the discovery and development of innovative drugs designed to address unmet medical needs. Key responsibilities • Optimize Lead Candidates: Drive humanization, affinity optimization, and the optimization of physicochemical properties to significantly improve the pharmacokinetics (PK), safety and efficacy of therapeutic antibodies. • Engineer Antibody Formats: Design, construct, and evaluate diverse antibody formats including bispecifics antibodies, antibody fragments, antibody-drug conjugates (ADCs), and fusion proteins, to achieve optimal structural stability, developability, and precise therapeutic functions. • Pioneer New Antibody Technologies: Lead the research and development of next-generation antibody platforms, novel discovery methodologies, and proprietary engineering technologies to expand the therapeutic pipeline and address complex disease targets. • Drive Cross-Functional Collaboration: Partner closely with diverse scientific departments such as target biology, pharmacology, and manufacturing to advance engineered therapeutics from discovery through development. Required Qualifications • PhD in Biomedical Science, Biochemistry, Chemical Biology, Biotechnology, Information Science, or a related discipline. • Demonstrated technical expertise in areas such as molecular biology, cell biology, protein chemistry, or protein engineering, evidenced by research projects, presentations, patents, and/or peer-reviewed publications. • Demonstrated strong expertise in at least one of the following areas: - Protein and/or antibody engineering, including rational or random mutagenesis approaches. - Structural and molecular biology for protein structure and function investigation. - Structural modelling and/or machine learning. - Protein biochemistry, including protein expression, purification, and characterisation. • Excellent organisational skills with the ability to manage and interpret large datasets. • Strong communication and collaboration skills, with the ability to work effectively in cross-functional and multidisciplinary teams. • Good command of spoken and written English. • Self-motivated team player with the capability of managing multiple priorities in a dynamic research environment. Preferred Qualifications • Prior work experience in antibody drug discovery. • Knowledge of high-throughput systems, automation, and/or general scripting languages. • Knowledge of cell biology, biophysics or immunology. Interested applicants are invited to email their detailed resume, as well as their qualifications, availability, current and expected salary to: recruitment@chugai-pharmabody.com For more information regarding our Company, you may refer to our website at: http://chugai-pharmabody.com/ We regret that only short-listed candidates will be notified